Thiotepa improves allogeneic bone marrow engraftment without enhancing stem cell depletion in irradiated mice

A novel factor V null mutation detected in a thrombophilic patient with pseudo-homozygous APC resistance and in an asymptomatic unrelated subject.

1. O’Brien SG, Goldman JM: Busulfan alone as cytoreduction before autografting for chronic myelogenous leukemia. Blood 91:1091, 1998 (letter) 2. Down JD, Ploemacher RE: Transient and permanent engraftment potential of murine hematopoietic stem cell subsets: Differential effects of host conditioning with gamma radiation and cytotoxic drugs. Exp Hematol 21:913, 1993 3. Down JD, Boudewijn A, van O...

Allogeneic Bone Marrow Engraftment Keratinocyte Growth Factor Improves

Marrow engraftment by allogeneic leukocytes in lethally irradiated dogs.

By R. STORB, R. B. EPSTEIN, H. RAGDE, J. BRYANT AND E. D. THOMAS A MAJOR PROBLEM of allogeneic bone marrow grafting in outbred animals and in man has been the procurement of a quantity of marrow from a single living donor sufficient for rapid restoration of marrow function.’ Recent studies in mice,2 guinea pigs,’ and dogs4 indicate that cells with marrow repopulation potential circulate in the ...

Marrow Engraftment by Allogeneic Leukocytes in Lethally Irradiated Dogs

By R. STORB, R. B. EPSTEIN, H. RAGDE, J. BRYANT AND E. D. THOMAS A MAJOR PROBLEM of allogeneic bone marrow grafting in outbred animals and in man has been the procurement of a quantity of marrow from a single living donor sufficient for rapid restoration of marrow function.’ Recent studies in mice,2 guinea pigs,’ and dogs4 indicate that cells with marrow repopulation potential circulate in the ...

Phenotypic characterization of a novel bone marrow-derived cell that facilitates engraftment of allogeneic bone marrow stem cells.

Bone marrow transplantation is an accepted therapy for hematologic malignancies, aplastic anemia, metabolic disorders, and solid tumors. However, graft-versus-host disease (GVHD) and failure of engraftment have limited the widespread application of this technology to nonmalignant disease states. The use of purified bone marrow stem cells has been suggested as an approach to promote engraftment ...